Endocrine Abstracts

Introduction: Thyroid hormones are the most important factors involved in the regulation of the basal metabolic state, as well as in the oxidative metabolism. Oxidative stress accompanying hyperthyroidism is caused by increased synthesis of reactive oxygen species (ROS) and changes in the antioxidant defence system.Aim of the study: To evaluate the pro-oxidant/antioxidant status and the effect of vitamin E supplementation in damage caused by the excessiv...

Introduction: Multiple Endocrine Neoplasia Syndrome 2B (MEN 2B) is a very rare genetic disorder which affects the thyroid and the adrenal glands, the development of mucosal neuromas and the general appearance of the patient’s body. Therefore, we can encounter Medullary Thyroid Carcinomas (MTC), adrenal sympathetic paragangliomas (or Pheochromocytomas) and habitus Marfanoid. The disease represents a challenge for every clinician, especially if it occurs in a child.<p c...

Background: Differentiated thyroid cancer (DTC) encompases a wide spectrum of disease from clinically insignificant micro-tumors to aggressive cancers. The molecular signature can be used to predict tumor behaviour, and the co-existence of BRAF and TERT promoter mutations has been identified as a marker of adverse prognosis, but we have yet no available molecular data for the Romanian population.Objectives: To determine the prevalence of BRAF V600E and T...

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by germline mutations of MEN1 gene, without genotype–phenotype correlation. It is defined as the occurrence of two or more primary neuroendocrine tumors (parathyroid, enteropancreatic, pituitary), or the occurrence of one of the MEN1-associated tumors in family members of a patient with a clinical diagnosis of MEN1. Multiple parathyroid tumors with hyperparathyroidism are the most common m...

Introduction: RET proto-oncogene is situated on chromosome 10 and encodes a tyrosine kinase receptor. A germline mutation of RET leads to the appearance of MEN 2 syndrome or familial medullary thyroid carcinoma (MTC). One of the most common germline mutation occurs in codon 634. Pheochromocytoma penetrance for codon 634 mutation was demonstrated to increase with age up to 88% by age 77 years.Aim: To present two familial cases of RET mutation illustrating...

Background: Surgery is the standard treatment in patients with medullary thyroid carcinoma (MTC), 43% being biochemically cured postoperative in a large series, the most important prognostic factor being the stage of the disease.Material and methods: We present 3 cases of biochemical cured patients after surgery with different preoperative presentation. Calcitonin and carcinoembryonic antigen (CEA) were measured by chemiluminescence. Histological examina...

Introduction: CD56 (neural cell adhesion molecule/NKH1/LEU19 and LEU7/NHK-1) is an antigen related to follicular epithelium differentiation.Materials and methods: We evaluated the expression of CD56 protein in normal follicular thyroid tissue, 15 non-neoplastic thyroid lesions (nodular hyperplasia–NH, Graves–Basedow disease (GB) and chronic lymphocytic/Hashimoto is thyroiditis (HT) and 38 thyroid neoplasias derived from follicular cells (25 PTC...

Introduction: The ectopic thymus tissue (ETT) represents a migration and descending deficiency of the organ during embryogenesis.HMWK have a strong positive reaction in normal anatomical localized thymus and thymomas. A similar reaction pattern is seen in thyroid solid cell nests (SCNs) suggesting that these cells share a common origin with thymic tissue. Moreover, can be very helpful in differentiate CASTLE from other thyroid tumors.<p class="abstex...

Introduction: Cytokeratin-19 (CK19), p53 and Ki-67 are some of the proposed markers for differentiating benign from malignant thyroid tumors.Material and method: We evaluated the tissue expression of the three markers in 60 thyroid lesions including: 8 cases of nodular hyperplasia (NH), 16 follicular adenomas (FA), 26 papillary carcinomas (PC) and 10 follicular carcinomas (FC). Tissue sections fixed in formalin and embedded in paraffin were immunohistoch...

Introduction: Primary hyperparathyroidism (PHP) affects predominantly the adult age (incidence 1/10 000) and it is unusual.The aim of the study: Is to present a rare pathology in a child, which implied interdisciplinary collaboration.Material and method: We present a teenager girl of 16 years old, diagnosed with osteomalacia after a thoracic and pelvis trauma, based on knee and pelvis radiographs (diffuse bone demineralization, tra...